Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration
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چکیده
منابع مشابه
Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD. The purpose of this study was to investigate the role of αB crystallin in sodium iodate (NaIO3)-induced retinal degeneration, a model of AMD in whi...
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SEPTOJOD,* which appears to have been introduced in 1920, has been used widely in German-speaking countries for septic conditions on the assumption that nascent iodine is liberated by this preparation in the presence of septic material. It has been especially popular in the treatment of puerperal sepsis. In 1926, Schimmel and Riehm reported two cases of blindness following the intravenous injec...
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Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract and its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (G...
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BACKGROUND Studies have shown that mini-αA can protect retinal pigment epithelium (RPE) cells from apoptosis. However, no in vivo study concerning the anti-apoptotic function of mini-αA has been conducted yet. METHODS MTT assay, HE staining and TUNEL assay were used to assess levels of cells, and an animal model was established to examine the protective effects of mini-αA against NaIO3-induce...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0098275